It is usually covered by Medicare and most insurance plans. If you use a SingleCare discount card for generic bupropion, the cost can be reduced to a more affordable price. Get the SingleCare prescription discount card. The generic version of Wellbutrin XL is typically covered by Medicare and other insurance plans. Check to see if your pharmacy accepts SingleCare cards for prescription discounts.
Other side effects involve the CNS central nervous system and include dizziness, insomnia, and anxiety. Wellbutrin can also cause gastrointestinal side effects such as stomach upset and constipation. Other common side effects may include heart palpitations, tremors, tinnitus ringing in the ears , muscle pain, and rash.
Weight loss and weight gain are other possible side effects associated with Wellbutrin. Serious side effects with Wellbutrin are rare and often associated with overdose. Serious side effects include hallucinations, arrhythmia heart rhythm problems , low blood pressure, and seizures. This may not be a complete list. Consult your doctor or pharmacist for other side effects.
Bupropion is processed in the liver by the CYP2B6 enzyme to form an active metabolite called hydroxybupropion. Drugs that block inhibit or stimulate induce this enzyme can alter the effects of bupropion. CYP2B6 inhibitors can increase the level of bupropion in the blood which can increase the risk of adverse effects. CYP2B6 inducers can lower blood levels of bupropion and decrease its effectiveness.
Bupropion can also affect the CYP2D6 enzyme and alter the effects of other drugs that are processed by it. Other drugs like monoamine oxidase inhibitors MAOIs can increase the risk of hypersensitivity reactions and adverse events. Drugs that lower the seizure threshold can increase the risk of seizures in those taking bupropion. This may not be a complete list of all possible drug interactions.
Consult a doctor with all medications you may be taking. Like other antidepressants, these medications should be monitored for new or worsening suicidal behavior. Those with a history of seizure disorders should consult a doctor before taking Wellbutrin. Taking Wellbutrin can increase the incidence of seizures. Wellbutrin has other precautions such as increases in blood pressure. The recommended starting dose of bupropion extended-release tablets for treatment of major depressive disorder is mg daily, taken in the morning.
This dose may be increased to mg daily after 1 week at the lower dose. For prevention of seasonal depression, this medication should be started in the autumn before symptoms of depression develop and continued through the winter.
The usual starting dose is mg taken once daily in the morning. It may be increased to mg taken once daily after 1 week at the lower dose. For people taking mg daily, the dose should be reduced to mg daily for 2 weeks prior to stopping this medication in the spring.
Bupropion extended-release tablets should be swallowed whole with fluids. They should not be chewed, crushed, or halved, as this may affect how this medication is absorbed by the body and result in unwanted side effects. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications.
If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Do not dispose of medications in wastewater e. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses.
Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome.
Your pharmacist may be able to advise you on managing side effects. Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
You can think of them as an internal messaging system for your body, delivering instructions between neurons and from neurons to other tissue. Norepinephrine is a neurotransmitter responsible for keeping your body alert and ready to act. It helps to increase your heart rate, pump blood throughout your body, keep you awake, alert and able to focus and recall important information. Dopamine is a neurotransmitter responsible for regulating learning, pleasure, motivation, sleep, mood and a variety of other important functions.
People with depression may have low levels of norepinephrine and dopamine. By blocking your brain from reabsorbing norepinephrine and dopamine, aminoketone medications such as Wellbutrin bupropion can increase norepinephrine and dopamine levels and treat the symptoms of depression. However, they believe that its effects on dopamine might be responsible for at least some of its effectiveness as a smoking cessation aid.
Instead, it may work by mimicking some of the effects of the nicotine in cigarettes, which also causes your brain to release extra dopamine. Bupropion is available in several dosages. Certain brands of bupropion may contain a different dosage per tablet. For depression, a typical starting dosage of bupropion is mg to mg per day, taken either as mg tablets taken twice per day or a single mg extended-release bupropion tablet taken in the morning.
The maximum dosage of bupropion for depression is mg to mg per day. After three to four days, you may need to adjust your dosage of bupropion. Follow the dosage instructions provided by your healthcare provider to make sure you take the right amount of bupropion.
For smoking cessation, a typical starting dosage is one mg extended-release tablet per day for the first three days, followed by a dosage of mg per day, taken as two tablets taken at least eight hours apart, from day four. Based on your symptoms, health history, response to the medication and several other factors, your healthcare provider may adjust your dosage of bupropion over time. Like all antidepressants, bupropion can cause certain side effects.
Most of the side effects that can occur with bupropion are minor and temporary. However, there are also several potentially severe side effects that you should be aware of before using this medication.
Some of the common side effects of bupropion include:. Many of these side effects may be mild and often disappear over the course of several days or weeks. In general, bupropion is less likely to cause sexual dysfunction than other commonly prescribed antidepressants, such as SSRIs and tricyclic antidepressants.
The risk of having a seizure increases with higher than recommended doses of bupropion, a history of seizures or head injury, tumor in the brain, severe liver disease, an eating disorder, alcohol or drug dependence, or taking other drugs that can also increase your risk of having a seizure.
There is a low risk of cardiovascular adverse events associated with stimulating agents, including bupropion. This risk increases if you have heart disease, high blood pressure, previous heart attack, or irregular heartbeat, or when used with transdermal nicotine replacement products.
In these cases, a thorough cardiovascular evaluation is recommended before starting this medicine. To date, there are no known problems associated with long term use of bupropion. It is a safe and effective medication when used as directed. Bupropion should not be taken with or within two weeks of taking monoamine oxidase inhibitors MAOIs. There are several products with the active ingredient bupropion.
Do not take more than one product that contains bupropion since this may increase your risk of having a seizure. Certain medications may increase your risk of having a seizure when combined with bupropion. These include other antidepressants, antipsychotics, theophylline, isoniazid, tramadol, stimulants, steroids, hypoglycemic agents including insulin , certain antibiotics e.
These medications can change the way your body reacts to bupropion. Bupropion can change the way your body reacts to these medications. Sleep, energy, or appetite may show some improvement within the first weeks.
Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in actiities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs.
In short-term studies, antidepressants increased the risk of suicidality in children, adolescents and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults ages 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment. Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication.
Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein.
The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein.
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